Rampias Theodoros

Investigator C – Assistant Professor Level

Biomedical research Foundation Academy of Athens

Dr. Theodoros Rampias earned his B.S. degree in Biological Sciences from the National and Kapodistrian University of Athens (NKUA) in 1996 and then joined Dr. Sideris laboratory at NKUA for his PhD Thesis studies, which were completed in 2004. During his Ph.D Thesis he characterized the genomic structure and the catalytic activity of the RNaseK ribonuclease.

He continued his research working as postdoctoral associate at the National Center for Scientific Research “Demokritos”, the Medical Oncology Department of Yale School of Medicine, the Department of Molecular Biophysics and Biochemistry of Yale University and the Biomedical Research Foundation of the Academy of Athens (BRFAA). His postdoctoral studies focused on mechanisms and consequences of cancer genome instability. In 2010, Dr. Rampias was appointed as Associate Research Scientist at the Yale School of Medicine and performed research on RAS-driven epithelial tumorigenesis.

Dr. Rampias returned to BRFAA in 2012 as a senior post-doctoral research scientist in Dr. Klinakis laboratory and studied the role of Notch as tumor suppressor gene in bladder epithelium. He also investigated the impact of cancer related epigenetic alterations on DNA damage response.

In 2019, Dr. Rampias was appointed as an Investigator C (Assistant Professor level) at the Center of Basic Research. His laboratory research focuses on mechanisms promoting genome integrity with an emphasis on the role of epigenome in DNA repair processes and gene expression regulation.

Selected Publications

 Rampias T, Karagiannis D, Avgeris M, Polyzos A, Kokkalis A, Kanaki Z, KousidouE, Tzetis M, Kanavakis E, Stravodimos K, Manola KN, Pantelias GE, Scorilas A,Klinakis A. The lysine-specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer. EMBO Rep. 2019 Mar;20(3). pii: e46821. doi:10.15252/

Rampias T. Vgenopoulou P. Avgeris M. Polyzos A. Stravodimos K. Valavanis C. Scorilas A, Klinakis A. A new tumor suppressor role for the Notch pathway in bladder cancer. Nature Medicine. 2014 Oct;20(10):1199-205.

Rampias T, Giagini A, Siolos S, Matsuzaki H, Sasaki C, Scorilas, A, Psyrri A. RAS/PI3K crosstalk and cetuximab resistance in head and neck squamous cell carcinoma. Clinical Cancer Research. 2014 20 (11), pp. 2933-2946.

Rampias T, Pectasides E, Prasad M, Sasaki C, Gouveris P, Dimou A, Kountourakis P, Perisanidis C, Burtness B, Zaramboukas T, Rimm D, Fountzilas G, Psyrri A. Molecular profile of head and neck squamous cell carcinomas bearing p16 high phenotype. Ann Oncol. 2013 Aug;24(8):2124-31

Rampias T, Sheppard K, Soll. The archaeal transamidosome for RNA-dependent glutamine biosynthesis. Nucleic Acids Res. 2010, 38:5774-5783

Rampias T, Sasaki C, Weinberger P, Psyrri A. E6 and E7 Gene Silencing and Transformed Phenotype of Human Papillomavirus 16-Positive Oropharyngeal Cancer Cells. J Natl Cancer Inst. 2009, 101:412-423.

Rampias T, Fragoulis EG, Sideris DC. A hybrid specific – PCR based amplification approach for chromosomal walking. Anal Biochem. 2009 ,388:342-344.

Rampias T, Fragoulis EG, Sideris DC. Genomic structure and expression analysis of the RNase kappa family ortholog gene in the insect Ceratitis capitata. FEBS J. 2008, 275:6217-6227.

Rampias T, Sideris DC, Fragoulis EG. Cc RNase: the Ceratitis capitata ortholog of a novel highly conserved protein family in metazoans. Nucleic Acids Res. 2003,31:3092-3100.